AstraZeneca Acquires EsoBiotec: A New Era for In Vivo Cell Therapy
May 7, 2025
At IGF, we keep a close eye on all the news in startups and innovations. That’s why, biotech area is not an exception. Recently, AstraZeneca acquired Belgian biotech startup EsoBiotec, a pioneer of in vivo cell therapies. And this is only one of the examples. The agreement, worth up to $1 billion, is about a major advancement in the scalability and effectiveness of new therapeutics.
Using In Vivo Delivery to Rethink Cell Therapy
An international, science-led biopharmaceutical corporation, AstraZeneca is dedicated to the discovery, development, and marketing of prescription drugs in the fields of oncology, rare diseases, and biopharmaceuticals. That’s why they follow all the interesting and innovative startups. This time, they put an eye on a unique ENaBL (Engineered NanoBody Lentiviral) platform created by EsoBiotec. The platform is revolutionizing the delivery of cell treatments. Cell therapy is typically a costly and time-consuming procedure that entails removing a patient’s cells, altering them in a lab, and then reinfusing them following immune system preparation.
On the other hand, EsoBiotec’s in vivo method uses lentiviral vectors to transfer genetic instructions straight into the body. What’s the result, you might ask? The result is a possible one-time IV treatment with no lengthy production times or immune cell depletion.
What This Signifies for Investors and Startups
This acquisition is more than simply a commercial transaction. It’s an indication that large pharmaceutical companies are increasingly funding innovative startups. AstraZeneca’s goal is to use the immune system to combat cancer and immunologically mediated disorders quickly and precisely. The advancement of it is the company’s integration of EsoBiotec’s technology into its own cell therapy pipeline.
This action highlights how innovative delivery technologies that can scale and reach larger patient populations are becoming increasingly valuable to investors and early-stage businesses. It also emphasizes the value of innovative startup teams and entrepreneurs who challenge the state of knowledge.
IGF vision
We, at IGF, are glad to see the upcoming generation of biotech entrepreneurs that, like EsoBiotec, are developing ground-breaking products. With the support of appropriate funding and strategic alliances, we believe they can achieve new heights in therapeutics.


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